The Leukocyte Nuclear Envelope Proteome Varies with Cell Activation and Contains Novel Transmembrane Proteins That Affect Genome Architecture*□S
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چکیده
Citation for published version: Korfali, N, Wilkie, GS, Swanson, SK, Srsen, V, Batrakou, DG, Fairley, EAL, Malik, P, Zuleger, N, Goncharevich, A, de Las Heras, J, Kelly, DA, Kerr, ARW, Florens, L & Schirmer, EC 2010, 'The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture' Molecular and Cellular Proteomics, vol 9, no. 12, pp. 2571-85. DOI: 10.1074/mcp.M110.002915
منابع مشابه
The Leukocyte Nuclear Envelope Proteome Varies with Cell Activation and Contains Novel Transmembrane Proteins That Affect Genome Architecture*
A favored hypothesis to explain the pathology underlying nuclear envelopathies is that mutations in nuclear envelope proteins alter genome/chromatin organization and thus gene expression. To identify nuclear envelope proteins that play roles in genome organization, we analyzed nuclear envelopes from resting and phytohemagglutinin-activated leukocytes because leukocytes have a particularly high ...
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One hypothesis to explain how mutations in the same nuclear envelope proteins yield pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners mediate the disease pathologies. The nuclear envelope proteome was recently determined from leukocytes and muscle. Here the same methodology is applied to liver and a direct comparison of the liver, muscle and leukocyte ...
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